Hugo Snippert

Lotte publishes experimental data in Cell reports that the number of functional stem cells increases in intestinal crypts upon caloric restriction, confirming prior studies using marker gene expression.

Most of our lab work has been restricted since half of March. After about two months, we are enthusiastic to slowly reopening the labs. Virtual meetings are likely to stay in some sort…

Thankful for our great and long-lasting collaboration with the Van Rheenen laboratory! New work, spearheaded by the Van Rheenen lab, in Cell Stem Cell about the origin of liver metastases from colorectal cancers. Using genetic mouse models and intravital imaging, it turns out that the major suspects, i.e. so-called cancer Read more

Hugo is a member of a multidisciplinary research team (AMOLF, NKI, Hubrecht & UMCU) that successfully applied for a NWO groot research grant (~€2,5M). The team will perform functional studies on rare cell types in the gut to delineate their relationship with common diseases like Crohn’s, obesity, infections or irritable Read more

We wrote a review about the types of oncogenic mutations in the MAPK pathway in colorectal cancer. They are similar but different. Unfortunately, studying them is often comparing apples to oranges. Organoid models and CRISPR genome editing might pave the way…

Michiel was awarded a prestigious Marie Curie research grant to continue his science in our lab after an earlier successful period at MSKCC in NY, USA. Well done! Michiel will study genetic alterations in esophageal adenocarcinoma using patient organoids and high-end imaging.

Jasmin successfully defended her thesis called ‘Similar but different: Oncogenic MAPK pathway mutations in colorectal cancer’. Jasmin is fully prepared to take on the business world. We wish her all the luck in her career and life.

We welcome two new PhD students to our team, J&J. As students, Julian and Joris have both been matured in our lab, with their grand finales at Rockefeller University (NY) and University of Cambridge (UK) respectively.

Proud to be one of the seven projects in the Organ-on-Chip Showcases call that have been awarded a grant by Top Sector Life Sciences & Health (Health~Holland). I will continue to explore the use of microfluidics (from industrial partner VyCAP) with live-cell imaging of organoids to study tumor evolution.

Koen successfully defended his thesis called ‘Cell fate dynamics in intestinal homeostasis and cancer’. He is now gone to the lab of Jacco van Rheenen (NKI, Amsterdam) in preparation to his upcoming adventure in the lab of Prisca Liberali (FMI, Basel). We wish him all the luck in science and Read more