Joris Hageman successfully defended his thesis ‘Phenotypic plasticity of human intestinal stem cells in regeneration and cancer’. He made such a great show of his defense, that he was awarded cum laude. Wow!!! Joris was our best in shaping beautiful looking Bonsai-organoids. We wish him all the best in his Read more
Intestinal tuft cells are epithelial sentinels that trigger host defense upon detection of parasite-derived compounds. Their functioning and differentiation are poorly understood because the cell type is rare. In Nature Communications we describe our developed reporters and optimized differentiation strategies in organoids, to generate a platform for studying immune-related tuft Read more
We cycled and ran the famous Tour de France col Alpe d’Huez to raise money for cancer research. We joined forces with many of our Oncode Institute colleagues to participate with fundraiser Alpe d’HuZes. What an experience
The complete Snippert lab moved to the Prinses Máxima Center in Utrecht. We will join forces with the strong organoid community in the Máxima, and explore new opportunities to widen our scope and foster our interest in preventing cancer.
Genetic mutations supposed to be permanent, and in stark contrast to the dynamic and reversible nature of cellular plasticity states. With a beautiful collaboration with Marnix Jansen lab in London, we report in Nature Genetics on something in middle, i.e. reversible DNA mutations!!! That is, we found various DNA repair Read more
Hugo received new funding from KWF (€820k), the Dutch Cancer Foundation, to strengthen our team with two new PhD students. We will use this support to make a deep dive into the tumor microenvironment of invasive fronts at the earliest stages of colorectal cancer formation.
Hugo received a prestigious ERC consolidator grant (€2,0M) from the EU in support of our studies to understand the evolution of the tumor genome during the earliest formation of colon cancer. The project will rely heavily on genome analysis at the single-cell level in both tumors and multi-regional organoid derivatives Read more
Beautiful ceremony in the Amsterdam Stedelijk Museum for modern art. AMMODO Science Award is a biannual prize for early-career scientists to continue their research line as they seem fit (€350k). Proud to be listed among all previous recipients. Thankful to all current and past team members, and colleagues in the Read more
Drug-resistant cells are often metabolically inactive, compromising the suitability of mostly used drug response assays on organoids. In this publication @Cell reports, we designed a novel microscopy-based drug screen that accurately distinguishes dead from alive organoids. We found microtubule-targeting agents, commonly used in clinical oncology, to eliminate RAS mutant cells Read more
Excited that Oncode Institute will continue to support fundamental research in our fight against cancer. Needless to say, we are proud to remain a member (senior now) and ready to roar!